Hyiodine represents a novel approach to healing chronic and complicated wounds. The product efficacy is based on the synergistic wound healing effect of hyaluronic acid and iodine complex. The unique combination links excellent regenerative properties and makes Hyiodine suitable for the treatment of chronic infected wounds.

Published clinical studies have been conducted on over 176 non-healing complex wounds including: pressure ulcers, diabetic foot ulcers, leg ulcers and surgical wounds. The studies resulted in 43% progressing to full healing and 36% significantly improving over the trial period.[Sobotka, 2011 ]

Hyiodine clinical studies

New studies published

Author(s) Title Publication
Sobotka, L., et al The Combination of Hyaluronate-Iodine Complex and Negative Pressure Therapy on Non-Healing Diabetic Wounds EWMA, 2014, poster View
Sobotka, L., et al The Combination of Negative Pressure and Hyaluronate-Iodine Dressing in Complicated Abdominal Wounds EWMA, 2014, poster View


Author(s) Title Publication
Brenes, R., et al Initial experience using a hyaluronate-iodine complex for wound healing The American Surgeon Journal, Volume 77 (March 2011) 355-359
Brenes, R., et al Hyaluronate-iodine complex compared to papain urea in the treatment of chronic and acute venous insufficiency wounds World Union of Wound Healing Societies, 2008, poster View
Brenes, R., Ajemian, S. et al Cumulative initial experience using hyaluronate-iodine complex in wound healing New England Surgical Society, 2008, poster View
Brenes, R., Sobotka, L. Hyaluronate-iodine complex. A new adjunct for the management of complex sternal wounds after a cardiac operation Arch Surg, 2011, 146 (11) 1323-1325
Cap, R., et al Effect of hyaluronate-iodine complex in skin grafting chronic infected wounds EWMA, 2008, poster View
Cutting, K. Wound healing through synergy of hyaluronan and an iodine complex JWC, 2011, 20 (9) 424-430 View
Cutting, K., Amlani, A., Barlow Kearsley, E. Hyiodine in action - The journey continues Diabetic Foot Supplement, 2011, 14 (4) 1-4 View
Frankova, J., et al The effect of hyaluronan combined with KI3 complex (Hyiodine wound dressing) on keratinocytes and immune cells J Mater Sci: Mater Med, 2006, 17, 891-898
Jarvie, G. Comparative study: Hyiodine vs. Standard care for post-operative management of nail avulsions Wounds UK, 2013, Poster
Oberreiter, M., et al Positive effect of hyaluronan-iodine complex in extensive war injury after failure of VAC therapy. A case report EWMA, 2012, poster View
Ott, K., et al Treatment of therapeutical resistant wounds with hyaluronan combined with bactericidal agent (hyaluronan iodine complex) first time experience in Switzerland Congress of Swiss Surgery, 2011, poster View
Parry-Ellis, R., Activating healing naturally in three complex ulcers using Hyaluronic Acid/Iodine Complex TVS, 2012, poster View
Plodr, M., et al Complex of Hyaluronic acid and iodine in war soft tissue injuries – first experience (case reports) Poster View
Ruzickova, J., et al Influence of sodium hyaluronate - iodine complex on human keratinocytes and leukocytes Advanced Wound Care, 2003, poster View
Sobotka, L., et al The Combination of Hyaluronate-Iodine Complex and Negative Pressure Therapy on Non-Healing Diabetic Wounds EWMA, 2014, poster View
Sobotka, L., et al The Combination of Negative Pressure and Hyaluronate-Iodine Dressing in Complicated Abdominal Wounds EWMA, 2014, poster View
Sobotka, L., Amlani, A., et al Hyiodine in action Diabetic Foot Supplement, 2011, 14 (3) 1-4
Sobotka, L., et al Successful treatment of surgical abdominal wounds complicated by multiple bowel fistulas with a combination of total parenteral nutrition, hyaluronan-iodine complex and delayed surgery: results of a monocentric experience Nutritional Therapy & Metabolism, 2008, 26 (4) 177-183
Sobotka, L., et al A case report of the treatment of diabetic foot ulcers using a sodium hyaluronate and iodine complex Lower Extremity Wounds, 2007, 6 (3) 143-147
Sobotka, L., et al Use of hyaluronate-iodine complex for the treatment of hepatic abscess cavities A.S.P.E.N, 2007, poster View
Sobotka, L., Velebny, V., et al Complex approach to the treatment of diabetic foot defects EWMA, 2006, poster View
Sobotka, L., Velebny, V., et al Hyaluronate-iodine complex new method in complicated cardio-surgical wound treatment Poster View
Stanway, S., et al Management of a chronic wound in an end of life patient using Hyiodine Wounds UK, 2011, poster View

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