MIST Therapy is supported by a vast array of clinical evidence and has recently been reviewed by NICE resulting in a research RCT following NICE guidance: “MIST Therapy system for the promotion of wound healing in chronic and acute wounds”.

MIST Therapy Meta-analysis

Eight peer-reviewed studies found to be consistent in both the treatment and control groups were pooled to review the effects of MIST Therapy on wound size, volume, pain and healing time.

Summary of findings:

• 85.2% area reduction in 7 weeks
• 79.7% volume reduction in 12 weeks
• 42% healed at 12 weeks (compared to 24% for standard care)
• Mean time to heal = 8.2 weeks
• 79% pain reduction*

MIST Therapy demonstrates remarkable consistency of reduction in wound area, volume, pain and healing times across a wide range of wounds

* MIST Therapy is not FDA approved for the reduction of pain. Further clinical research is required.

MIST Clinical Studies

	Author(s)	Title	Publication
1	Driver, V., Yao M., Miller, C.	Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: A meta analysis	Wound Repair & Regeneration, 2011; 19 (4) 475:480	View
2	Ennis, WJ. et al.	Ultrasound Therapy for recalcitrant diabetic foot ulcers: Results of a randomised, double-blind controlled, multicentre study	Ostomy Wound Management, 2005, 51 (8) 24-39	View
3	Kavros, SJ., Miller JL, Hanna, SW.	Treatment of ischaemic wounds with noncontact, low-frequency ultrasound: the Mayo Clinic experience 2004-2006	Adv Skin Wound Care, 2007 20 (4) 221-226	View
4	Serena, T., et al	The impact of noncontact, nonthermal, low-frequency ultrasound on bacterial counts in experimental and chronic wounds	Ostomy Wound Management, 2009, 55 (1) 22-30	View
5	Gehling, ML, Samies, JH.	Unanticipated palliative benefit of noncontact, low-intensity, low-frequency therapeutic ultrasound on lower extremity chronic wound pain	Ostomy Wound Management, 2007, 53 (3) 44-50
6	Kavros, SJ., et al	Expedited wound healing with noncontact low-frequency ultrasound therapy in chronic wounds: A retrospective analysis	Adv Skin Wound Care, 2008, 21 (9) 416-423	View
7	Bell, AL., Cavorsi, J.	Noncontact ultrasound therapy for adjunctive treatment of non-healing wounds:  Retrospective analysis	Physical Therapy, 2008, 88 (12) 1517-1524	View
8	Cole, PS., Melin, MM., Quisberg, J.	Adjuvant use of acoustic pressure wound therapy for the treatment of chronic wounds	J Wound Ostomy Continence Nursing, 2009, 36 (2) 171:177	View
9	Hann, LS.,	A retrospective analysis of acoustic pressure wound therapy: effects on the healing progression of chronic wounds	J Amer College of Certified Wound Specialists, 2009, 1 (1) 28:34	View
10	Ennis, WJ. et al	Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds	Adv Skin Wound Care, 2006; 19 (8) 437:446	View
11	Kavros, SJ., Schenck EC.	Use of noncontact low-frequency ultrasound in the treatment of chronic foot and leg ulcerations : A 51 patient analysis	J Am Pod Med Assn., 2007, 97 (2) 95-101	View
12	Escandon,  J., et  al.	A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers	International Wound Journal, 2012, 9 (5) 570:578	View
13	Fabbi	Clinical and Biological Effects of Noncontact Low-Frequency Ultrasound on Diabetic Foot Ulcers	SAWC, 2011	View
14	Kavros, S.J., et al	The Effect of Ultrasound Mist Transfer Technology on Virulent Bacterial Wound Pathogens.	Abstract. Presented at Symposium on Advanced Wound Care, 2002.
15	Data on file at Celleration
16	Leidl, D.A., Kavros, S.J.	The Effect of Mist Ultra-sound Transport Technology on Cutaneous Microcirculatory Blood Flow.	Abstract. Presented at Symposium on Advanced Wound Care, 2001.
17	Lai., JY., Pittelkow, MR.	Physiological effect of ultrasound MIST on fibroblasts	Int J Dermatol, 2007, 46 (6) 587-593	View
18	Thawer, HA., Houghton, PE.	Effects of ultrasound delivered through a mist of saline to wounds in mice with diabetes mellitus	J Wound Care, 2004, 13 (5) 171-6	View
19	Driver, VR.,  Yao, M.	A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers	International Wound Journal, 2012, Nov-19 on-line publication	View
20	Seth, AK., et al	Noncontact, low frequency ultrasound as an effective therapy against pseudomonas aeruginosa – infected biofilm wounds	Wound Regeneration & Repair, 2013, 21 (2) 266:274	View
21	Norris, R., Driver, V., et al	Meeting Report: MIST ultrasound therapy: the science and the benefits	Wounds UK, 2011, 7 (1)130:137	View
22	Honaker, JS., et al	Effects of noncontact low-frequency ultrasound on healing of suspected deep tissue injury: A retrospective analysis	International Wound Journal, 2013, 10 (1) 65:72	View
23	Jordan, J.	A case study using MIST Therapy to heal chronic non-healing wounds	Wounds UK, 2012 (poster)
24	Edwards, V., Edwards, J.,	The use of MIST Therapy on an elderly burn patient	Wounds UK, 2011 (poster)	View
25	Furlong, W., Abbot, J., George, J.	The use of MIST Therapy on chronic wounds	Wounds UK, 2011 (poster)	View
26	Murray, S.	The effects of MIST Therapy on the debridement of an ulcer to a lower limb extremity	Wounds UK, 2011 (poster)	View
27	Chadwick, P.	The use of MIST Therapy in the management of complex diabetic foot wounds	Wounds UK, 2010 (poster)	View
28	Lara, L.,	MIST Therapy helped to save a foot from amputation	Wounds UK, 2010 (poster)	View
29	Stanway, S., Coop, R. et al	The management of chronic wounds using MIST	Wounds UK, 2010 (poster)	View
30	Norris, R., Henchy, R.	Use of low frequency ultrasound therapy in the treatment of recalcitrant leg ulcers: case series	Wounds UK, 2010, 6 (2)	View

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